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ELMO1

[engulfment and cell motility gene-1] ELMO1 (84 kDa) is one mammalian homolog of the Caenorhabditis elegans gene CED12. The cDNA encoding ELMO1 has been identified independently as KIAA0281. Two closely related proteins are ELMO2 and ELMO3.

The functions of this proteins and its interaction partners have been conserved in evolution (Gumienny et al, 2001). In mammalian cells, ELMO1 functionally cooperates with Crk-2 (CED2 homolog) and DOCK180 (CED5 homolog) to activate RAC1 (CED10 ... ... ... ... ... Subscribe to continue reading! ... ...

 

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