CED5
The Caenorhabditis elegans gene CED5 has been isolated initially as a gene affecting the elimination of cells undergoing cell death by apoptosis (Ellis et al, 1991). The mammalian homolog of CED5 is DOCK180 (see also: CDM).
CED5 has been shown to bind to another Caenorhabditis elegans protein, CED12. This complex causes the activation of a third gene product, CED10 (RAC1 homolog), and this, in turn, leads to rearrangements of the cytoskeleton. The functions of these proteins and their interaction partners have been conserved in evolution (Gumienny et al, 2001). In mammalian
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