ORFV125

[orf virus ORFV125 protein] This gene is encoded by the parapoxvirus orf virus. The encoded protein shows sequence and secondary-structure similarities to BCL2 family members.

ORFV125 can fully inhibit UV-induced DNA fragmentation, caspase activation, and cytochrome C release and thus protects cells against cell death by apoptosis. Mitochondrial localization of the protein is required for this. The viral protein can inhibit the UV-induced activation of the pro-apoptotic BCL2 family members BAX and BAK. Westphal et al (2009) have reported that the viral protein interacts with a range of BH3-only proteins ( ... ... ... ...
 
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Entry last modified: January 2015