ORFV121 |
ORFV127 |
C5FW |
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This gene is encoded by the parapoxvirus orf virus. The encoded protein shows sequence and secondary-structure similarities to BCL2 family members.
ORFV125 can fully inhibit UV-induced DNA fragmentation, caspase activation, and cytochrome C release and thus protects cells against cell death by apoptosis. Mitochondrial localization of the protein is required for this. The viral protein can inhibit the UV-induced activation of the pro-apoptotic BCL2 family members BAX and BAK. Westphal et al (2009) have reported that the viral protein interactes with a range of BH3-only proteins (BIK, PUMA,
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