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BCL2

(B-cell lymphoma/leukemia-2) An oncogene located on human chromosome 18q21 identified originally as a novel transcript associated with the t(14;18) chromosomal breakpoint which occurs in most follicular lymphomas. The protein is expressed also in a variety of other tissues.

The gene contains three exons and extends over at least 370 kb. It codes for a protein of 239 amino acids (BCL2-alpha; 26 kDa) that is located in the inner mitochondrial membrane. A shorter splice form of BCL2 (BCL2-beta; 22 kDa) lacks the hydrophobic transmembrane domain ... ... ... ... ... Subscribe to continue reading! ... ...

 

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