xR11

The cDNA encoding xR11 has been isolated from a Xenopus laevis stage 28-30 embryonic head cDNA library. The gene is widely expressed in Xenopus laevis embryos and tadpoles. The cDNA shows substantial homology with BCLxL and contains conserved BH1 and BH2 BCL2 homology domains.

Constitutive expression of xR11 in cultured rat fibroblasts (Rat-1) cells conferred a strong protection against cell death induced by the cytotoxic agents staurosporine and cycloheximide, by serum deprivation and specific deregulation of c-myc.

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Entry last modified: September 2012