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fibroblasts

[fibroblast]

Fibroblasts are the most ubiquitous cell type within the body and have long been considered to be important structural elements of tissue integrity. It has been recognized that fibroblasts, or distinct subpopulations thereof, perform functions that go beyond that of structural elements. Tissue-specific fibroblasts play an important role as immunoregulatory cells (see also: sentinel cells) that can mount and influence immune responses by being able to secrete chemokines and cytokines, which are able to trigger immune responses by attracting inflammatory cells and immune cells (Smith et al, 1997; Buckley et al, 2001; Kaufman et al, 2001; Silzle et al, 2003, 2004)

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