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gliotoxin

This biochemically uncharacterized factor of 17 kDa has been found in the conditioned medium of monocytes and macrophage multiple sclerosis patients. It is found also in the cerebrospinal fluid of patients with active disease. The factor induces cell death of primary mouse cortical glial cells, mouse immortalized astrocytes, and oligodendrocytes in vitro (Ménard et al, 1997).

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