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RC38

RC38 is a monoclonal antibody that reacts with renal proximal epithelium. RC38 reacts with 46/47 primary renal cell carcinomas tested and with 8/13 metastases. No reaction is seen with 179 tumors of various origin (Oosterwijk et al, 1986). The antibody recognizes a 160 kDa protein identified as aminopeptidase A and reacts with pericytes after cell activation and does not react with cultured human endothelial cells (Schlingemann et al, 1996) and is found also on endometrial cells and podocytes (see individual cell types for references).

In the nomenclature of CD antigens this protein has been given the designation CD249.

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