NLRP3 inflammasome

The NLRP3 inflammasome is one of several molecular assemblies known as inflammasome, which can process the precursor of IL1-beta and/or IL18. It is composed of NLRP3 (a member of the NLR family), the molecular adaptors CARD8 and ASC, and caspase-1 (Agostini et al, 2004).

The NLRP3 inflammasome has been shown to contributes to the metabolic pathogenesis during obesity and to metaflammation. Knock-out mice lacking the NLRP3 inflammasome are protected significantly against high-fat diet-induced obesity, insulin resistance, glucose intolerance, and inflammation. These animals show attenuated production of ... ... ... ...
 
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Entry last modified: February 2015