CARD7 |
CARD9 |
factor activating ExoS |
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[caspase recruitment domain-containing protein-8] CARD8 has been described independently as TUCAN, NDPP-1, CARDINAL, Dacar, and KIAA0955.
Razmara et al (2002) have shown that CARD8 interacts physically with caspase-1 and negatively regulates generation of IL1-beta mediated by caspase-1 in the THP-1 monocytic cell line. CARD8 also binds to ICEBERG and pseudo-ICE, which bind to the CARD domain of caspase-1 and negatively regulate its activity. CARD8 inhibits the activation of NF-kappa-B by TNF-alpha and by ectopically expressed RICK
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