IL17-Th2 cells |
IL18 binding protein |
Alpha-Taxilin |
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[Interleukin-18] The gene encoding this nonglycosylated protein of 24 kDa has been identified originally as IGIF (IFN-gamma inducing factor). It encodes an inducer of IFN-gamma production by T-cells (Okamura et al, 1995; Micalef et al, 1997) and natural killer cells (Tsutsui et al, 1996) that is a more potent inducer than IL12. Alternative designations are IL1-gamma and IL1F4. Human recombinant IL18 is marketed as Iboctadekin (GlaxoSmithKline).
The proteins from murine (192 amino acids) and human IL18 (193 amino acids) sources show 65 % homology. Rat and murine
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