LTBP4

[Latent TGF-beta binding protein-4] LTBP4 is one of four extracellular matrix glycoproteins complexing TGF-beta isoforms in a latent form that allows targeting and activation of this growth factor (see also: LTBP1, LTBP2, LTBP3) (Oklu and Hesketh, 2000).

A cDNA encoding a protein of 1587 amino acids (LTBP4L; latent TGF-beta binding protein-4L) has been isolated from human heart and melanoma gene libraries (Giltay et al, 1997; Saharinen et al, 1998). The mRNA is expressed highly in heart but is present also in skeletal muscle, pancreas, placenta and lung.

The protein is secreted into the ... ... ... ...
 
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Entry last modified: September 2005