LTBP3

[Latent TGF-beta binding protein-3] LTBP3 is one of four extracellular matrix glycoproteins complexing TGF-beta isoforms in a latent form that allows targeting and activation of this growth factor (see also: LTBP1, LTBP2, LTBP4) (Oklu and Hesketh, 2000).

The LTBP3 gene was isolated from a NIH 3T3 cell cDNA library (Yin et al, 1995). The deduced polypeptide contains 15 copies of an EGF-like repeat, 3 TGF binding protein repeats, and 2 proline- and glycine-rich sequences. It shows 38.4 % identity with LTBP1. The protein forms a complex with the TGF-beta-1 ... ... ... ...
 
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Entry last modified: September 2005