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ADNF

[activity-dependent neurotrophic factor] This protein is secreted into the conditioned medium of astroglial cells in the presence of the neuropeptide VIP. At femtomolar concentrations it protects neurons from cell death by apoptosis associated with electrical blockade by tetrodotoxin. ADNF also protects neurons against apoptosis induced by amyloid beta-peptide, N-methyl-D-aspartate, tetrodotoxin, HIV envelope coat protein gp120, oxidative stress, and trophic factor withdrawal (Brenneman et al, 1996; Glazner et al, 1999, 2000). Some peptides derived from ADNF show the same activities as the parent protein. ... ... ... ... ... Subscribe to continue reading! ... ...

 

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