gp120

[HIV-1 gp120] gp120 is the viral coat protein responsible for HIV-1 entry. When gp120 binds to CD4, it undergoes a series of structural changes that allows it to interact with receptors of chemokines (CCR5 and CXCR4), which function as co-receptors. Receptor binding eventually triggers conformational changes in another viral protein, gp41, which result in the formation of a fusion active molecule to attack the cell membrane. gp120 is shed from infected cells and thus can interact with distant uninfected cells. For abioactive cryptic peptide fragment of gp120 see also: EDAF [Env-derived antiviral factor].

gp120 can induce ... ... ... ...
 
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Entry last modified: June 2011