embryonal carcinoma cells |
embryonal stem cell gene 1 |
TNF-alpha converting enzyme |
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abbr. ECDGF (a term with multiple meanings). This heparin binding factor of 17.5 kDa is obtained from the conditioned medium of embryonal carcinoma cells (PC13 cell line) grown in serum-free medium (see also: SFM).
The factor is a member of the heparin binding growth factor protein family (see: HBGF; see also: gene family). It induces the proliferation of PC13 cells, of its differentiated variants, and also of murine 3T3 fibroblasts. Treatment of PC13 cells with ECDGF reduces the numbers of high-affinity receptors for EGF.
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