HB-GAM |
HBGF-0.8 |
macrophage galactose-specific lectin-2 |
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[heparin binding growth factors] This is a generic term to describe factors that can be isolated by affinity chromatography on Heparin-Sepharose columns (HSAC = Heparin-Sepharose affinity chromatography) due to their very high affinity for heparin (Hearn et al, 1987; Lobb et al, 1986). See also: heparin binding domain.
The ability to bind to heparin appears to be a general property of many growth-regulating factors (Burgess and Maciag, 1989). HSAC is therefore a technique employed frequently to isolate new growth factors from tissues, serum, or the conditioned medium of cultured cells, allowing their purification almost in a single step.
Two classes of heparin binding growth factors
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