BLOS2 |
BLP |
hematopoietic endothelial progenitor cells |
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This secreted murine protein (164 amino acids; 56 % similarity with gastrokine-1) has been identified by Otto et al (2006) in a search for binding factors for one of the members of the trefoil factor family, TFF-2. Cultured HT-29 cells express blottin and show increased DNA synthesis with anti-blottin antibody, an effect that is reversed by the immunizing peptide. The authors have suggested that Blottin may play a role in gastrointestinal mucosal protection and modulate gut epithelial cell proliferation.
Owing to sequence similarity with gastrokine-1 the protein has been renamed gastrokine-2.
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