XTC-MIF

[XTC mesoderm inducing factor] This heterodimeric factor, isolated from Xenopus laevis cells, is a member of the transforming growth factor-beta family (see: TGF-beta). Antibodies directed against TGF-beta-2 block the muscle inducing activity of XTC- cell conditioned medium.

The first inductive interaction in amphibian development is mesoderm induction, when a signal from the vegetal hemisphere of the blastula induces mesoderm from overlying equatorial cells. Mesoderm inducing factors cause isolated Xenopus laevis animal caps to form mesodermal cell types ... ... ... ...
 
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Entry last modified: August 2000