VEGF-165b |
VEGF-165 receptor |
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[VEGF-165 receptor] The cDNA for this receptor has been cloned from tumor cells by Soker et al (1998). The receptor is specific for VEGF-165 and does not bind another isoform of VEGF, VEGF-121. The receptor is identical with human NRP1 [neuropilin-1], which is also a receptor for a protein family mediating neuronal cell guidance, known as semaphorins.
When the isoform-specific receptor is coexpressed with KDR, another VEGF receptor, neuropilin-1 enhances the binding of VEGF-165 to KDR and also
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