U2 snRNA |
U2-related peptide |
BDGF-B |
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This cell line with epithelial morphology has been established by Ponten and Saksela from an osteosarcoma of a 15-year old Caucasian female. The cells have been used for a variety of studies of growth arrest, cell cycle control and cell death by apoptosis.
US-OS are resistant to TNF-alpha. Cell death by apoptosis in U2-OS cells induced by Apoptin is prevented by Adenovirus E1B 19 kDa protein but not by expression of BCL2. The viral protein causes the retention of apoptin in the cytoplasm, which prevents its nuclear function.
PDGF-B has been implicated as a participant in an autocrine
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