Adenovirus Death Protein |
Adenovirus E1B-55K protein |
marginal metallophils |
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a protein encoded in the genome of human adenoviruses. The gene encoding this protein is expressed early during viral replication cycle and possesses a variety of functions in the transformation of primary rodent cells and gene transcription. The protein facilitates efficient virus replication by protecting cells against premature cell death by apoptosis induced by another viral protein, E1A. Expression of the viral protein also prevents apoptosis induced by various external stimuli, including TNF-alpha and APO-1. Tollefson et al (2001) have shown that Adenovirus E1B 19 kDa protein prevents apoptosis of virus-infected human cells induced by TRAIL
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