Regulated necrosis

The term regulated necrosis has been used following the observation that necrosis, instead of being some kind of accidental cell death caused by severe (non-physiological) physical and/or chemical insults, can occur also in a highly regulated and genetically controlled manner (for overview see: Vanden Berghe T et al, 2014; Tonnus et al, 2019; Yu J et al, 2020). Regulated necrosis is a cell death modality caused by intrinsic factors and has been termed also Active necrosis (active necrotic cell death) in some publications.

Regulated necrosis may, for example, be triggered by exposure to alkylating DNA damage, excitotoxins and the ligation of death receptors ... ... ... ...
 
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Entry last modified: September 2021