regulated in development and DNA damage response 2 |
regulated upon activation normal T-cell expressed, and presumably secreted |
RH2 |
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The term regulated necrosis has been used following the observation that necrosis, instead of being some kind of accidental cell death caused by severe (non-physiological) physical and/or chemical insults, can occur in a highly regulated and genetically controlled manner (for overview see: Tonnus et al, 2019).
Regulated necrosis may, for example, be triggered by exposure to alkylating DNA damage, excitotoxins and the ligation of death receptors (Cho et al, 2011; He et al, 2009; Zhang DW et al, 2009; Zong WX et al, 2004; Bano et al, 2005). The term is used frequently synonymously with necroptosis, but is used also in a more general sense for different kinds of necrotic cell death and their underlying distinct molecular pathways, comprising ETosis,
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