death receptor
[death receptors]
This term refers to members of a growing family of transmembrane proteins that detect specific extracellular death signals. Engagement of these receptors by their respective ligands (death ligand) rapidly triggers cell death by apoptosis by recruiting adaptor proteins, which in turn recruit initiator caspases, giving rise to a pro-apoptotic complex termed the DISC (death-inducing signaling complex).
Known death receptors include FAS antigen (APO-1), TNF receptor-1, TRAMP (DR3), TRAIL-R1 (DR4, APO-2), TRAIL-R2 (
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