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RdCVF2

[Rod-derived cone viability factor 2] This protein has been identified by Chalmel et al (2007). The approved gene symbol is NXNL2 [nucleoredoxin-like 2]. It is known also as C9orf121 [chromosome 9 open reading frame 121].

The protein is related to thioredoxin and exists in two splice variants. RdCVF2 shares many similarities with RdCVF. The RdCVF2 short isoform is a trophic factor for photoreceptor cells (rod cells). The longer isoform (RdCVF2L) may have thiol-oxydoreductase activity. Unlike RdCVF, RdCVF2 long isoform mRNA is expressed also in other tissues such as tumor, testis, stem cells ... ... ... ... ... Subscribe to continue reading! ... ...

 

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