PY |
PYCS |
SLAM family member 1 |
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This protein contains a pyrin homology domain and a CARD domain. It is identical with ASC and TMS1, both of which are implicated in cell death by apoptosis. The new designation is CARD5. PYCARD has been shown to be a component of the inflammasome, and is required for the activation of caspases that process the proform of the inflammatory cytokine IL1-beta (for overview see Martino et al, 2001).
For other entries pertaining to cell death mechanisms see also the Apoptosis and Cell Death Dictionary section of this encyclopedia.
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