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NGIF

[neuroblastoma growth inhibitory factor] This biochemically uncharacterized factor (75 kDa by gel filtration) has been observed in the conditioned medium of normal rat glioblasts. Cell growth rates and DNA synthesis in neuroblastoma cells (Neuro2a, NS-20Y, and N1E-115) cultured in the presence of NGIF are markedly inhibited. The factor induces morphological differentiation including neural process formation. NGIF does not alter the growth rate or the morphology of non-neuronal cells such as glial cell lines (C6 and 354A) or fibroblasts (3T3 ... ... ... ... ... Subscribe to continue reading! ... ...

 

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