Fisp-12

[fibroblast inducible secreted protein-12] This immediate-early gene is transcriptionally activated upon growth factor stimulation in fibroblasts. Fisp-12 is the mouse homolog of the human CTGF [connective tissue growth factor] and is a member of the CCN family of proteins (Ryseck et al, 1991; Kireeva et al, 1997).

Fisp-12 enhances DNA synthesis induced by FGF. The activities of Fisp-12 and Cyr-61 are nearly indistinguishable in fibroblasts, endothelial, and epithelial cells. Unlike Cyr-61, Fisp-12 is also found in conditioned medium of ... ... ... ...
 
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Entry last modified: January 2012