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Encephalomyocarditis virus viroporin 2B

abbr. EMCV viroporin 2B; EMCV 2B protein [Encephalomyocarditis virus 2B protein]. This protein is a non-structural protein encoded by encephalomyocarditis virus.

Ito et al (2012) have reported that encephalomyocarditis virus activates the NLRP3 inflammasome in mouse dendritic cells and macrophages and that the EMCV viroporin 2B is sufficient to cause inflammasome activation in macrophages primed with LPS. EMCV 2B protein specifically reduces [Ca2+]ER/Golgi, stimulates IL1-beta secretion, and induces the redistribution of NLRP3 to the perinuclear region.

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