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large external transformation-sensitive protein
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[Endothelial cell neutrophil-activating peptide] This factor is isolated from activated human endothelial cells. It leads to cell activation of neutrophils and is a strong chemoattractant for these cells (see also: Chemotaxis).
The factor occurs in two forms, designated ENAP-alpha (7.5 kDa) and ENAP-beta (17 kDa), respectively. They are identical in their biochemical properties and biological activities with two other Neutrophil-activating proteins (see: MONAP, LYNAP). Both factors are identical with one of the molecular forms of IL8.
The new designation for ENAP-beta is CXCL8 and the gene symbol is SCYB8.
See REFERENCES for entry ENAP.
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