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ECK

[Epithelial cell kinase] The cDNA encoding this receptor protein tyrosine kinase has been cloned by Lindberg and Hunter, 1990) who also named it ECK. Another designation for this receptor is EphA2 (see: Ephrins).

ECK mRNA is overexpressed in melanoma cell lines (Easty et al, 1995). Levels are significantly higher in cell lines from distant metastases than primary melanomas; melanocytes are negative. The ligand for ECK, which induces autophosphorylation of ECK, is B61.

One of the intracellular signal transducing molecules associating with ECK is SLAP (src-like adapter protein), a protein with ... ... ... ... ... Subscribe to continue reading! ... ...

 

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