DEDD2

(approved gene symbhol) [death effector domain-containing DNA-binding protein-2] this protein is related to DEDD and contains a death effector domain (Roth et al, 2002). An alternative name is FLAME-3. Highest levels of DEDD2 mRNA are found in human adult liver, kidney, and peripheral blood leukocytes. DEDD2 interacts with FLIP, but not with FADD or caspase-8. Overexpression of DEDD2 induces moderate apoptosis and results in substantial sensitization to apoptosis induced by FAS antigen, TRAIL, or FADD. Expression of DEDD2 does not affect apoptosis mediated by ... ... ... ...
 
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Entry last modified: July 2008