CHOPPER

Name given to the cytoplasmic juxtamembrane region of the p75 neurotrophin receptor (p75NTR), which behaves like a death domain and has been found to be necessary and sufficient to initiate neural cell death by apoptosis (Coulson et al, 2000).

A peptide of 29 amino acids corresponding to this region induces apoptotic cell death in a variety of neural and non-neural cell types. Cell death is not inhibited by signaling through Trk receptor. CHOPPER triggers cell death only in a lipid-anchored membrane form. Non-anchored CHOPPER acts in a dominant-negative manner and blocks cell death mediated by p75NTR ... ... ... ...
 
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Entry last modified: May 2015