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Btf

[BCL2-associated transcription factor] The approved gene symbol for the human factor is BCLAF1 [BCL2-associated transcription factor 1]. The cDNA has been cloned independently as KIAA0164.

Btf has been identified in a yeast two-hybrid system as a protein that interacts with Adenovirus E1B 19 kDa protein and with the anti-apoptotic proteins BCL2 and BCLxL. Btf does not interact with the pro-apoptotic protein BAX (Kasof et al, 1999).

The gene is expressed widely. Overexpression of Btf in HeLa cells induces cell death by ... ... ... ... ... Subscribe to continue reading! ... ...

 

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