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BIK-like killer protein

abbr. BLK (a term with multiple meanings). BLK is a murine protein with a BH3 BCL2 homology domain. It is structurally and functionally related to human BIK. The protein is localized to the mitochondrial membrane and has been shown to interact with BCL2 and BCLxL.

Ectopic expression of BLK in mammalian cells induces cell death by apoptosis. Death can be inhibited by mutations in the BH3 domain and by overexpression of BCL2 or BCLxL. The inhibitory protein crmA ... ... ... ... ... Subscribe to continue reading! ... ...

 

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