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BDGI

[BMSC-derived growth inhibitor] This protein 477 amino acids has been identified by Wang et al (2004) in human bone marrow stromal cells. The C-terminal 317 residues are identical to a pregnancy-induced growth inhibitor (OKL38). The approved gene symbol is OSGIN1 [oxidative stress induced growth inhibitor 1].

Overexpression of BDGI has been shown to suppress the anchorage-dependent growth and migration of MCF-7 human breast cancer cells, and A549 lung cancer cells, inducing cell cycle arrest and cell death by apoptosis. These effects are not seen in HeLa ... ... ... ... ... Subscribe to continue reading! ... ...

 

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