BDGI

[BMSC-derived growth inhibitor] This protein 477 amino acids has been identified by Wang et al (2004) in human bone marrow stromal cells. The C-terminal 317 residues are identical to a pregnancy-induced growth inhibitor (OKL38). The approved gene symbol is OSGIN1 [oxidative stress induced growth inhibitor 1].

Overexpression of BDGI has been shown to suppress the anchorage-dependent growth and migration of MCF-7 human breast cancer cells, and A549 lung cancer cells, inducing cell cycle arrest and cell death by apoptosis. These effects are not seen in HeLa ... ... ... ...
 
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Entry last modified: August 2013