Ancestim |
Anchorage-independent growth |
PK2 |
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[anchorage dependence, anchorage-dependent growth, anchorage-dependent, anchorage-dependent cell]
A term used to characterize cells requiring a solid substratum for growth, i.e., the solid glass or plastic surface of a culture dish or micro-carrier beads. Anchorage-dependend cells do not grow in suspension cultures or semi-solid soft agar (see also: Colony formation assay). In some cases such cells are subject to a special form of cell death called Anoikis.
Most normal cells derived from solid animal tissues are anchorage-dependent and show a finite life span. Loss of anchorage dependence is usually a sign of cell transformation. Chondrocytes
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