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xDR-M1

A receptor with a death domain identified in Xenopus laevis (Tamura et al, 2004). For a related protein (71.7 % identity) see: xDR-M2.

Overexpression of xDR-M1 induces cell death by apoptosis. The effect is blocked by ageneral serine protease inhibitor, but not by an inhibitor of caspase-8. Ishizawa YH et al (2006) have reported that xDR-M1 interacts with Xenopus laevis FADD, RIP1, and its splice variant RIP1-beta.

For other entries pertaining to cell death mechanisms see also the Apoptosis and Cell Death Dictionary section of this encyclopedia.

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