viral MIP-2
abbr. vMIP-2. Also: vCCL2 [viral CCL2]. This secreted protein (73 amino acids) is a virokine encoded in the genome of KSHV and is variously being referred to as KSHV viral MIP-2 or HHV-8 viral MIP-2. The solution structure of viral MIP-2 has been determined by Liwang et al (1999). The protein is the viral homolog of one of the chemokines, MIP-2.
The protein acts as a broad-spectrum antagonist of various chemokines. viral MIP-2 has been shown to bind with high affinity to various receptors for chemokines (CCR1, CCR2, CCR5,
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