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[CCR2(+), CCR2(-)]

[CC-Chemokine receptor 2] Two cDNAs that encode MCP-1 receptors have been isolated. The encoded proteins are seven transmembrane-spanning G-protein-coupled receptors that have been termed CC-CKR2A or CCR2A; CC-CKR2B or CCR2B; MCP-1 receptor A and MCP-1 receptor B) (Charo et al, 1994; Combadiere et al, 1995). The CCR2A and CCR2B isoforms are the result of alternative splicing and differ in their carboxyl tails and 3' untranslated regions. In transfected cells, CCR2B is expressed at the cell surface and in the cytoplasm, whereas CCR2A ... ... ... ... ... Subscribe to continue reading! ... ...


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