serum response element |
serum response factor accessory protein |
ACDCR1 |
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[serum response factors]
abbr. SRF (a term with multiple meanings). A dimeric phosphorylated transcription factor of 67 kDa (see also: gene expression) that specifically binds to serum response elements (see: SRE) in the promoters of some cytokine genes and other genes the expression of which is inducible by cytokines and growth factors. See also: Response elements.
SRF modulates the binding of another protein (p62TCF = ternary complex factor) to the serum response element. p62TCF interacts with SRF and also binds to sequences in the vicinity of CArG box (see: SRE
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