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rcm

[Rostral cerebellar malformation protein] rcm is a recessive mutation in the mouse that causes a disorderly arrangement of Purkinje and granule cells in the rostral portion of the cerebellum (Lane et al, 1992).

Ackerman et al (have cloned the rcm cDNA and shown that it encodes a transmembrane receptor of the immunoglobulin superfamily. The sequence of the rcm protein is highly similar to that of UNC5, a Caenorhabditis elegans protein essential for dorsal guidance of pioneer axons and for the movement of cells away from the netrin ligand. Sequence analysis shows that rcm encodes UNC5H3 (UNC5C).

Kuramoto et al (2004) have shown that rats ... ... ... ... ... Subscribe to continue reading! ... ...

 

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