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induced hematopoietic stem cells

abbr. iHSC. These cells have been described by Riddell et al (2014). They are derived from committed lymphoid progenitor cells and myeloid progenitor cells and myeloid effector cells by reprogramming, using transient expression of six transcription factors Run1t1, Hlf, LMO2, Prdm5, Pbx1, and Zfp37. This procedure imparts multilineage transplantation potential onto these otherwise committed progenitor cells. The reprogrammed cells possess clonal multilineage differentiation potential, reconstitute stem cell and progenitor compartments, and are serially transplantable. The cells exhibit a gene expression ... ... ... ... ... Subscribe to continue reading! ... ...

 

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