Fragile site FRA16D oxidoreductase |
fragilis2 |
GAPDH(230-243) |
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The expression of the mouse fragilis gene is associated with the acquisition of germ cell competence by epiblast cells. Extraembryonic ectoderm is able to induce fragilis expression in epiblasts, and this requires the participation of BMP4 (Saitou et al, 2002). An alternative designation for fragilis is IFITM3 [interferon-induced transmembrane protein 3]. For related genes see also: fragilis2, fragilis3. Sallman Almen M et al (2012) have referred to the protein as DSPA2c [Dispanin subfamily A member 2c], identified as a member of a larger family of transmembrane proteins termed
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