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fibroblast collagenase inhibitor

Fibroblast collagenase inhibitor is a collagenase inhibitor secreted by human skin fibroblasts and is found also in human serum (Stricklin and Welgus, 1983). The protein isolated previously from serum as a gamma-serum protein and termed Beta-1 anticollagenase or B1 anticollagenase (Woolley et al, 1975) is thought to be identical with fibroblast collagenase inhibitor (Cawston et al, 1986). Carmichael et al (1986) have purified secreted human Fibroblast collagenase inhibitor and also cloned the corresponding cDNA. Sequence analysis shows that this protein is the same as TIMP-1.

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