baculovirus p35 protein |
BACURD2 |
INWKKIAEIGKQVLSAL |
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This protein (49 kDa) is encoded by a gene in the genome of Spodoptera littoralis nucleopolyhedrovirus and is being referred to also as sl-p49 (Spodoptera littoralis nucleopolyhedrovirus p49 protein) or P49. (Pei et al, 2002). It is a homolog of baculovirus p35 protein. P49 prevents cell death by apoptosis in invertebrates by inhibiting one of the initiator caspases that is insensitive to the action of baculovirus p35 protein. P49 also inhibits human caspase-9 (Zoog et al, 2002). Inhibition of insect and human caspases requires cleavage of
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