Baculovirus expression system |
baculovirus P49 protein |
MM cells |
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The Autographa californica nuclear polyhedrosis virus (AcMNPV, baculovirus) gene (AcMNPV p35) encoding the 35 kDa protein is a cell survival protein that functions as an inhibitor of virus induced apoptosis in insect cells (Clem et al, 1991). The protein is being referred to also as caspase inhibitor p35 or simply as p35. This inhibitor has been identified in several types of baculoviruses and has been shown to function in a variety of different species. A related protein is baculovirus P49 protein.
p35 is capable of blocking, for example, developmentally programmed cell death in the nematode Caenorhabditis elegans
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