APOE*4 |
apoE(133-167) |
apoptosis and splicing associated protein |
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[apolipoprotein E(133-150)] This bioactive peptide, LRVRLASHLRKLRKRLLR, corresponds to residues 133-150 of human apolipoprotein E (see also: cryptides) (Pane et al, 2016). The peptide possesses a broad-spectrum antibacterial activity and is active against Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus aureus, Bacillus subtilis. ApoE(133-150) is not toxic toward several human cell lines (HeLa, HEK cells, Caco-2 cells, THP-1 monocytes, keratinocytes). The peptide triggers a significant innate immune response
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