Zincoptosis

this term has been suggested in analogy to ferroptosis and cuproptosis (Tkachenko A and Onishchenko A, 2023). There does not seem to be any experimental evidence that zincoptosis exists as a unique cell death modality with a unique signaling cascade. Zinc plays a role as an ionic mediator of neuronal excitotoxic cell death (Koh JY et al, 1996), but dying neurons show features of apoptosis and regulated necrosis (for overview see: Kim YH et al, 2020).

Zhao Y et al (2022) have reported that excessive zinc activates endoplasmic reticulum stress in the ischemic brain and that zinc-induced cell death of neurons is at least partially due to apoptosis ... ... ... ...
 
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Entry last modified: March 2024