Z-FA-fmk
[Z-Phe-Ala-fmk; benzyloxycarbonyl-phe-Ala-fluoromethylketone] This compound is a very potent irreversible inhibitor of the cysteine protease Cathepsin B (Smith et al, 1988). The compound has been shown to prevent production of IL1-alpha, IL1-beta, and TNF-alpha induced by LPS in macrophages by inhibiting NF-kappapB pathways.
Z-FA-fmk is employed frequently as a control inhibitor in studies of caspases and their involvement in cell death by apoptosis. Lopez-Hernandez et al (2003) have reported that Z-FA-fmk can inhibit caspase activity in vitro and selectively inhibits recombinant effector caspases, caspase-2, caspase-3,
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